生物纳米技术课题组

(Biotechnology Group)

  • 组内新闻(News):

2019917日,祝贺夏永清、陈炳鹤、高帅等的论文“Tough, Freestanding, and Colorless Photonic Paper Using Water as Ink, Advanced Materials Interfaces, DOI:10.1002/admi.201901363 在线发表”。

2019年9月7日,欢迎2019级研究生刘阳、徐晓敏、梁雨薇、于荣华、徐鲁艺、梁金辉开学报到进入课题组。

201999日,祝贺曹美文、王瑜等的论文“Reversible Thermoresponsive Peptide–PNIPAM Hydrogels for Controlled Drug Delivery, Biomacromolecules, 20, 3601-3610发表

2019630日,祝贺曹美文、邢蕊蕊、常蕊等的论文“Peptide-coordination self-assembly for the precise design of theranostic nanodrugs, Coordination Chemistry Reviews, 397, 14-27 在线发表

2019年6月21日,祝贺在实验室进行本科毕业论文工作的党梦涛同学(指导教师:曹美文)的论文获得“校级优秀毕业论文”。

2019618日,祝贺硕士研究生卢沙、唐大超、张晓同学获得硕士学位

2019612日,祝贺夏永清、吴寒、唐大超等的论文“Graphene Oxide Nanosheet-Composited Poly(N-isopropylacrylamide) Hydrogel for Cell Sheet Recovery, Macromolecular Research, DOI:10.1007/s13233-019-7099-z 在线发表”。

2019611号,祝贺王生杰老师等的山东省重点研发计划项目(公益性科技攻关类)获批立项。

2019521日,祝贺崔丙顺同学获得“专业学位研究生优秀实践成果奖”二等奖。

2019年4月16日,祝贺曹美文、卢沙、王宁宁等的论文“Enzyme-Triggered Morphological Transition of Peptide Nanostructures for Tumor-Targeted Drug Delivery and Enhanced Cancer Therapy”被ACS Applied Materials & Interfaces接收,DOI: 10.1021/acsami.9b03519

2019415日,祝贺王生杰、部勇、王晓娟等的专利一种短肽/二氧化硅/透明质酸复合水凝胶的制备方法(201611114226.X获得授权。

2019412号,祝贺曹美文、徐海、王继乾等的专利“一种自组装抗菌肽(专利号:201610265536.5)”获得授权。

2019125日,祝贺王生杰、崔丙顺、蔡庆伟等的论文“Fabrication of highly luminescent SiO2-Au nanostructures and application in detection of trace Hg2+”Journal of Materials Science 接收。

201918日,祝贺曹美文、沈阳、王瑜等的论文“Self-Assembly of Short Elastin-like Amphiphilic Peptides: Effects of Temperature, Molecular Hydrophobicity and Charge Distribution, Molecules, 2019, 24(1), 202在线发表”。

20181225日,祝贺王生杰、张董秀、张晓等的论文 “Short peptide-regulated aggregation of porphyrin for photoelectric conversion” Sustainable Energy & Fuels接收。

20181120号,祝贺王生杰,张董秀,部勇等的专利“一种具有光捕获功能的多级复合微胶囊的制备方法(专利号:201610649240.3)”获得授权。

2018107号,祝贺王生杰,徐海,蔡庆伟等的专利“一种用于Hg2+检测的SiO2/Au纳米复合材料及其制备方法(专利号:201610308709.7)”获得授权。

2018917日,祝贺曹美文老师等的国家自然科学基金面上项目“基于多肽/DNA超分子组装构筑的人工病毒(21872173)”获批立项。

2018725日,祝贺曹美文、王瑜、赵文婧等论文“Peptide-Induced DNA Condensation into Virus-Mimicking Nanostructures, ACS Applied Materials & Interfaces, 2018, 10(29), 24349-24360”在线发表。

2018725日,祝贺曹美文、赵文婧等论文“Graphene Oxide-Assisted Accumulation and Layer-by-Layer Assembly of Antibacterial Peptide for Sustained Release Applications, ACS Applied Materials & Interfaces, 2018, 10(29), 24937-24946”在线发表。


  • 成员(Members


教师

王生杰 副教授;夏永清 副教授;曹美文 副教授

StaffDr WANG Shengjie; Dr XIA Yongqing; Dr CAO Meiwen


在读研究生

王瑜、沈阳、崔丙顺、荆倩、高帅、陈秉鹤、修阳、刘方园、曽竹君、玄甲明、聂焱、丁榛、刘阳、徐晓敏、梁雨薇、于荣华、徐鲁艺、梁金辉

MSc students:

WANG Yu, SHEN Yang, CUI Bingshun, JING Qian, GAO Shuai, CHEN Binghe, XIU Yang, LIU Fangyuan, ZENG Zhujun, XUAN Jiaming, NIE Yan, DING Zhen, LIU Yang, XU Xiaomin, LIANG Yuwei, YU Ronghua, XU Luyi, LIANG Jinhui


已毕业学生:

部勇、谢子龙、唐颖、赵文婧、吴寒、张董秀、张晓、唐大超、卢沙

Former students:

BU Yong, XIE Zilong, TANG Ying, ZHAO Wenjing, WU Han, ZHANG Dongxiu


  • 研究方向(Research):

  1. 仿生光电功能材料(Functional Biomimetic Photoelectric Materials

  2. 仿生矿化(Biomineralization

  3. 纳米生物医用材料(Nano Biomedical Materials

  4. 功能性两亲分子体系开发及应用(Development & Application of Functional Amphiphiles

  5. 多功能纳米材料 (Multifunctional Nanomaterials)

  6. 肿瘤标记以及靶向给药 (Tumor Labelling and Target Drug Delivery)


  • 承担项目(Grants & Projects

一、基础研究项目:

  1. 国家自然科学基金面上项目(21872173),基于多肽/DNA超分子组装构筑的人工病毒及其应用

  2. 国家自然科学基金面上项目(21773310),离子掺杂二氧化钛的仿生合成、结构控制及光催化性质

  3. 国家自然科学基金面上项目(21473255),两亲性短肽的细胞内自组装

  4. 国家自然科学基金青年基金(21003160),肽核酸(PNA)基两亲分子的设计、合成及性质研究

  5. 国家自然科学基金项目(20804057),氨基酸-肽高分子水凝胶的仿生矿化及其在骨组织工程中的应用研究

  6. 国家自然科学基金青年基金(21103229),超短肽介导的二氧化硅仿生矿化及构性调控研究

  7. 山东省自然科学基金面上项目(ZR2015BM013),透明仿生界面的构建及在乳腺循环肿瘤细胞捕获与释放中的应用

  8. 山东省自然科学基金青年基金(ZR2009BQ003),完全氨基酸构成的Gemini两亲分子的设计、合成及自组装

  9. 山东省自然科学基金青年基金(Q2008B03),氨基酸-肽高分子水凝胶的仿生矿化及其在仿生骨材料中的应用

  10. 山东省自然科学基金青年基金(ZR2009B0014),智能型高载药超支化大分子前药的设计、合成及控释行为研究

  11. 教育部博士点新教师基金项目(200804251527),以天然生物高分子为基质的可注射水凝胶的制备及其在组织工程中的应用

  12. 教育部博士点新教师基金项目(200804251523)双亲性超支化聚酯基大分子前药的合成及控释行为研究

  13. 教育部博士点新教师基金项目20090133120007),Gemini型肽基双亲分子的设计、合成及自组装行为研究

  14. 高校自主创新项目(17CX02050),生物响应性药物载体的构筑及应用

  15. 高校自主创新项目(15CX05017A),多尺度有序二氧化钛的仿生制备及在光化学转化中的应用

  16. 高校自主创新项目(14CX02055A),PNA-DNA相互作用及其AFM单分子力谱研究



  • 代表性论文(Selected Publications

  1. Cao, M.*, Wang, Y., Hu, X. et al., Reversible Thermoresponsive Peptide–PNIPAM Hydrogels for Controlled Drug Delivery. Biomacromolecules. 2019, 20 (9), pp.3601.

  2. Cao, M.*, Lu, S., Wang, N, Xu, H., Cox, H. et al., Enzyme-Triggered Morphological Transition of Peptide Nanostructures for Tumor-Targeted Drug Delivery and Enhanced Cancer Therapy. ACS Applied Materials & Interfaces. 2019, 11 (18), pp.16357.

  3. Cao, M.*, Xing, R., Chang, R., Wang, Y., Yan, X. Peptide-coordination self-assembly for the precise design of theranostic nanodrugs. Coordination Chemistry Reviews. 2019, 397: 14-27.

  4. Wang, S.*; Cui, B.; Cai, Q.; Bu, Y.; Wang, X.; Cao, M; Xia, Y.; Hua, H.. J. Mater. Sci. 2019, DOI: 10.1007/s10853-019-03391-1.

  5. Wang, S.*; Zhang, D.; Zhang, X.; Yu, D.; Jiang, X.; Wang, Z.; Cao, M.; Xia, Y.; Liu, H. Short peptide-regulated aggregation of porphyrin for photoelectric conversion. Sustainable Energy & Fuels. 2019, DOI: 10.1039/C8SE00523K.

  6. Cao, M.*, Shen, Y., Wang, Y., Wang, X., Li, D. Self-Assembly of Short Elastin-like Amphiphilic Peptides: Effects of Temperature, Molecular Hydrophobicity and Charge Distribution. Molecules. 2019, 24(1): 202.

  7. Cao, M.*, Wang, Y., Zhao, W., Qi, R., Han, Y., Wu, R., Wang, Y., Xu, H.* Peptide-Induced DNA Condensation into Virus-Mimicking Nanostructures. ACS Applied Materials & Interfaces. 2018, 10 (29), pp.24349.

  8. Cao, M.*, Zhao, W., Wang, L., Li, R., Gong, H., Zhang, Y., Xu, H.*, Lu, J.R.* Graphene Oxide-Assisted Accumulation and Layer-by-Layer Assembly of Antibacterial Peptide for Sustained Release Applications, ACS Applied Materials & Interfaces. 2018, 10 (29), pp.24937.

  9. Xia, Y.*, D. Tang, H. Wu, X. Wang, M. Cao, H. He and S. Wang*, Cell attachment/detachment behavior on poly(N-isopropylacrylamide)-based microgel films: the effect of microgel structure and swelling ratio. J. Mater. Sci., 2018, 53, 8795-8806.

  10. Wang, S.*; Li, M.*; Patil, A. J.; Sun, S.; Tian, L.; Zhang, D.; Cao, M.; Mann, S.* Design and construction of artificial photoresponsive protocells capable of converting day light to chemical energy. J. Mater. Chem. A, 2017, 5, 24612.

  11. Du, M.; Bu, Y.; Zhou, Y.; Zhao, Y.; Wang, S.*; Xu, H*. Peptide-templated synthesis of branched MnO2 nanowires with improved electrochemical performances. RSC Adv. 2017, 7, 12711.

  12. Xia, Y. *, Tang, Y., Wu, H., Zhang, J., Li, Z., Pan, F., Wang, S., Wang, X., Xu, H., Lu, J.R.* Fabrication of Patterned Thermoresponsive Microgel Strips on Cell-Adherent Background and Their Application for Cell Sheet Recovery. ACS applied materials & interfaces. 2017;9:1255-1262.

  13. Cao Meiwen et al., Peptide nucleic acid-ionic self-complementary peptide conjugates: highly efficient DNA condensers with specific condensing mechanism, RSC Advances, 2017, 7, 3796.

  14. Cao Meiwen et al., Direct exfoliation of graphite into graphene in aqueous solutions of amphiphilic peptides, Journal of Materials Chemistry B, 2016, 4, 152.

  15. Xia, Y.*, Tang, Y., He, X., Pan, F., Li, Z., Xu, H., Lu, J.R.* Patterned Thermoresponsive Microgel Surfaces to Control Cell Detachment. Biomacromolecules. 2016;17:572-579.

  16. Wang, S.*; Cai, Q.; Du, M.; Xue, J.; Xu, H*. Synthesis of 1D Silica Nanostructures with Controllable Sizes Based on Short Anionic Peptide Self-Assembly J. Phys. Chem. B 2015, 119, 12059.

  17. Wang, S.; Xue, J., Zhao, Y.; Du, M.; Deng, L.; Xu, H. *; Lu, J. R. Controlled silica deposition on self-assembled peptide nanostructures via varying molecular structures of short amphiphilic peptides. Soft Matter 2014, 10, 7623.

  18. Xia, Y., He, X., Cao, M., Wang, X., Sun, Y., He, H., Xu, H., Lu, J.R. Self-Assembled Two-Dimensional Thermoresponsive Microgel Arrays for Cell Growth/Detachment Control. Biomacromolecules. 2014;15:4021-4031.

  19. Xia, Y., He, X., Cao, M., Chen, C., Xu, H., Pan, F., Lu, J.R. Thermoresponsive Microgel Films for Harvesting Cells and Cell Sheets. Biomacromolecules. 2013;14:3615-3625.

  20. Wang, S.; Xue, J.; Ge, X.; Fan, H.; Xu, H. *; Lu, J. R*. Biomimetic synthesis of silica nanostructures with controllable morphologies and sizes through tuning interfacial interactions. Chem. Commun. 2012, 48: 9415.

  21. Xia, Y., Gu, Y., Zhou, X., Xu, H., Zhao, X., Yaseen, M., Lu, J.R. Controllable Stabilization of Poly(N-isopropylacrylamide)-Based Microgel Films through Biomimetic Mineralization of Calcium Carbonate. Biomacromolecules. 2012;13:2299-2308.

  22. Wang, S., Ge, X.; Xue, J.; Fan, H.; Mu, L.; Li, Y.; Xu, H. *; Lu, J. R*. Mechanistic Processes Underlying Biomimetic Synthesis of Silica Nanotubes from Self-Assembled Ultrashort Peptide Templates. Chem. Mater. 2011, 23, 2466.


  • 授权专利(Patents

  1. 曹美文,赵文婧,谢子龙,卢沙,徐海. 一种酶响应性自组装肽及其应用(专利号:ZL201710223136.2

  2. 曹美文,徐海,王继乾,王宁宁,谢子龙,赵文婧. 一种自组装抗菌肽(专利号:ZL201610265536.5

  3. 王生杰,徐海,杜明轩,王栋,邓礼. 一种三维支化二氧化锰纳米材料的制备方法(专利号:ZL201610352477.5

  4. 王生杰,徐海,杜明轩,部勇,王继乾,孙亚伟. 一种一维TiO2/SiO2纳米光催化材料的制备方法(专利号:ZL201610264185.6

  5. 王生杰,徐海,蔡庆伟,王晓娟,曹美文. 一种用于Hg2+检测的SiO2/Au纳米复合材料及其制备方法(专利号:201610308709.7

  6. 王生杰,张董秀,部勇,夏永清. 一种具有光捕获功能的多级复合微胶囊的制备方法(专利号:201610649240.3

  7. 曹美文,王玉鸣,徐海,汪蕾. 一种增加井壁稳定性并降低滤失的方法(专利号:ZL201410502665.2

  8. 曹美文,徐海,王玉鸣,王宁宁,汪蕾. 一种石墨烯分散剂及石墨烯分散液的制备方法(专利号:ZL201410532476.X

  9. 曹美文,徐海,汪蕾,王继乾,王栋,吕建仁. 一种高强度多肽水凝胶的制备方法(专利号:ZL201510697529.8

  10. 曹美文,徐海,汪蕾,王玉鸣,陈翠霞,吕建仁. 一种高载药量的长效缓释抗菌薄膜及其制备方法(专利号:ZL201510794371.6